A Periodical for the Sarcoma Community

October 2009 - Volume 6, Number 5

A Dilemma for the Informed Patient

Editorial by Bruce Shriver, PhD

The Difficulty and Promise of Immunotherapy for Sarcomas

CTOS Op Ed: Dr. Robert Maki discusses problems with immunotherapy in the treatment of sarcomas.

Targeting EWS-FLI1 with Small Molecule Inhibitors

In this study report, Dr. Jeffrey Toretsky discusses important principles in the creation of small molecules that disrupt protein-protein interactions.

The Role of CIP4 in Osteosarcoma

In this study report, Dr. Nadezhda Koshkina provides information that indicates CIP4 may become a new target for OS treatment.

The Ewing's Sarcoma Stem Cell

In this study report, Dr. David Loeb discusses work that demonstrates that a subpopulation of Ewing sarcoma cells characterized by high expression of aldehyde dehydrogenase has characteristics of stem cells.

Deletion of the WWOX Gene and Frequent Loss of its Protein Expression in Human Osteosarcoma

Dr. Jilong Yang and Dr. Wei Zhang describe work that this implies that epigenetic changes such as promoter methylation are early events in the pathogenesis of osteosarcoma.

Children, Adolescents and Young Adults: A Review of Recent Articles

Elizabeth Goldstein-Rice discusses the results of several studies about children, adolescents and young adults dealing with cancer.